Publications
Yeung ST, Ovando LJ, Russo AJ, Rathinam VAK, Khanna KM. CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis. Cell Reports. Cell Rep. 2023 Mar 28;42(3):112171. doi: 10.1016/j.celrep.2023.112171. Epub 2023 Mar 2.PMID: 36867536
Bee GCW, Lokken-Toyli KL, Yeung ST, Rodriguez L, Zangari T, Anderson EE, Ghosh S, Rothlin CV, Brodin P, Khanna KM, Weiser JN. Age-depedent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. Immunity. 2023 Apr 5:S1074-7613(23)00138-3. doi: 10.1016/j.immuni.2023.03.018. Online ahead of print.PMID: 37059107
Chen F, El-Naccache DW, Pnessa JJ, Lemenze A, Espinosa V, Wu W, Lothstein K, Jin L, Antao O, Weinstein JS, Damani-Yokota P, Khanna K, Murray PJ, Rivera A, Siracusa MC and Gause WC. Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion. Cell Reports. 2022; 38(2), 1033-1035.
Damani-Yokota P, Yeung ST, Khanna KM. Beyond neutralization for BNT162b2 mRNA vaccination. Cell Host Microbe. 2021 Jul 14;29(7):1033-1035. doi: 10.1016/j.chom.2021.06.013. PMID: 34265240; PMCID: PMC8279510.
Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9. PMID: 34048708; PMCID: PMC8106883.
Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, García-Sastre A, Blander JM. TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nat Immunol. 2021 Apr;22(4):497-509. doi: 10.1038/s41590-021-00903-7. Epub 2021 Mar 31. PMID: 33790474.
Sulaiman I, Chung M, Angel L, Tsay JJ, Wu BG, Yeung ST, Krolikowski K, Li Y, Duerr R, Schluger R, Thannickal SA, Koide A, Rafeq S, Barnett C, Postelnicu R, Wang C, Banakis S, Perez-Perez L, Jour G, Shen G, Meyn P, Carpenito J, Liu X, Ji K, Collazo D, Labarbiera A, Amoroso N, Brosnahan S, Mukherjee V, Kaufman D, Bakker J, Lubinsky A, Pradhan D, Sterman DH, Weiden M, Hegu A, Evans L, Uyeki TM, Clemente JC, De Wit E, Schmidt AM, Shopsin B, Desvignes L, Wang C, Li H, Zhang B, Forst CV, Koide S, Stapleford KA, Khanna KM, Ghedin E, Segal LN. Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258. doi: 10.1038/s41564-021-00961-5. Epub 2021 Aug 31.PMID: 34465900
Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020 Dec 23;183(7):2036-2039. doi: 10.1016/j.cell.2020.12.008. Erratum for: Cell. 2020 Jan 9;180(1):79-91.e16. PMID: 33357400; PMCID: PMC7891798.
Ryu S, Shchukina I, Youm YH, Qing H, Hilliard BK, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna KM, Horvath TL, Dietrich MO, Artyomov MN, Wang A, Dixit VD. Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. bioRxiv [Preprint]. 2020 Sep 12:2020.09.11.294363. doi: 10.1101/2020.09.11.294363. Update in: Elife. 2021 Jun 21;10: PMID: 33236006; PMCID: PMC7685240.
Imperato JN, Xu D, Romagnoli PA, Qiu Z, Perez P, Khairallah C, Pham QM, Andrusaite A, Bravo-Blas A, Milling SWF, Lefrancois L, Khanna KM, Puddington L, Sheridan BS. Mucosal CD8 T Cell Responses Are Shaped by Batf3-DC After Foodborne Listeria monocytogenes Infection. Front Immunol. 2020 Sep 11;11:575967. doi: 10.3389/fimmu.2020.575967. PMID: 33042159; PMCID: PMC7518468.
Das Mohapatra A, Tirrell I, Benechet AP, Pattnayak S, Khanna KM, Srivastava PK. Cross-dressing of CD8α+ dendritic cells with antigens from live mouse tumor cells is a major mechanism of cross-priming. Cancer Immunol Res. 2020 Aug 5:canimm.0248.2020. doi: 10.1158/2326-6066.CIR-20-0248. Online ahead of print.PMID: 32759362
Ural BB, Yeung ST, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, Samji T, Sawai CM, Jang G, Perez OA, Pham Q, Maher L, Loke P, Dittmann M, Reizis B, Khanna KM. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties. Sci Immunol. 2020 Mar 27;5(45):eaax8756. doi: 10.1126/sciimmunol.aax8756.PMID: 32220976
Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12. PMID: 31406379
Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. Systemic TLR2 tolerance enhances central nervous system remyelination. J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID: 31351476
Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21. PMID: 30799265
Masters AR, Jellison ER, Puddington L, Khanna KM, Haynes L. Attrition of T Cell Zone Fibroblastic Reticular Cell Number and Function in Aged Spleens. Immunohorizons. 2018 May;2(5):155-163. doi: 10.4049/immunohorizons.1700062. Epub 2018 Jul 23. PMID: 30706058
Grenier JM, Yeung ST, Khanna KM. Combination Immunotherapy: Taking Cancer Vaccines to the Next Level. Front Immunol. 2018 Mar 22;9:610. doi: 10.3389/fimmu.2018.00610. eCollection 2018. Review. PMID: 29623082
Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA. Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction. PLoS One. 2018 Mar 8;13(3):e0194053. doi: 10.1371/journal.pone.0194053. eCollection 2018. PMID: 29518138
Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM. Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective against Solid Skin Tumors. Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017. PMID: 29387061
Huang K, Mukherjee S, DesMarais V, Albanese JM, Rafti E, Draghi Ii A, Maher LA, Khanna KM, Mani S, Matson AP. Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. Pediatr Res. 2018 May;83(5):1031-1040. doi: 10.1038/pr.2018.14. Epub 2018 Feb 21. PMID: 29360809
Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM. CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Sci Immunol. 2017 Oct 6;2(16). pii: eaah5520. doi: 10.1126/sciimmunol.aah5520. PMID: 28986418
Menon M, Benechet AP, Khanna KM. Visualizing Endogenous Effector T Cell Egress from the Lymph Nodes. Methods Mol Biol. 2017;1591:59-71. doi: 10.1007/978-1-4939-6931-9_5. PMID: 28349475
Samji T, Khanna KM. Understanding memory CD8+ T cells. Immunol Lett. 2017 May;185:32-39. doi: 10.1016/j.imlet.2017.02.012. Epub 2017 Mar 6. Review. PMID: 28274794
Qiu Z, Cervantes JL, Cicek BB, Mukherjee S, Venkatesh M, Maher LA, Salazar JC, Mani S, Khanna KM. Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4. Sci Rep. 2016.
Romagnoli PA, Fu HH, Qiu Z, Khairallah C, Pham QM, Puddington L, Khanna KM, Lefrancois L, Sheridan BS. Differentiation of distinct long-lived memory CD4 T cells in intestinal tissues after oral Listeria monocytogenes infection. Mucosal Immunol. 2016.
Romagnoli PA, Sheridan BS, Pham QM, Lefrancois L, Khanna KM. IL-17A-producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection. Proc Natl Acad Sci USA. 2016;113(30):8502-7.
Svedova J, Tsurutani N, Liu W, Khanna KM, Vella AT. TNF and CD28 signaling play unique but complementary roles in the systemic recruitment of innate immune cells after staphylococcus aureus Enterotoxin A inhalation. J Immunol. 2016;196(11):4510-21.
Benechet AP, Menon M, Xu D, Samji T, Maher L, Murooka TT, Mempel TR, Sheridan BS, Lemoine FM, Khanna KM. T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection. Proc Natl Acad Sci USA. 2016;113(8):2182-7.
Qiu Z, Grenier JM, Khanna KM. Reviving virus based cancer vaccines by using cytomegalovirus vectors expressing modified tumor antigens. Oncoimmunology. 2015;5(1):e1056974.
Sharma N, Benechet AP, Lefrançois L, Khanna KM. CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues. J Immunol. 2015;195(11):5227-36.
Plumlee CR, Obar JJ, Colpitts SL, Jellison ER, Haining WN, Lefrançois L, Khanna KM. Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection. Sci Rep. 2015;5:12264.
Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S. Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease. PLoS Pathogen. 2015;11(6):e1004975.
Fujiwara M, Anstadt EJ, Khanna KM, Clark RB. Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720. Clin Immunol. 2015;158(1):103-13.
Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, Khanna KM. Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8(+) T-cell Response and Protects Mice from Melanoma. Cancer Immunol Res. 2015;3(5):536-46.
Benechet AP, Menon M, Khanna KM. Visualizing T Cell Migration in situ. Front Immunol. 2014;5:363.
Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM*, Mani S*. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 2014;41(2):296-310. *Co-corresponding Authors.
Wu T, Hu Y, Lee Y-T, Bouchard KR, Benechet A, Khanna K, Cauley LS. Lung-resident memory CD8 T cells (TRM) are indispensible for optimal cross-protection against pulmonary virus infection. J Leukoc Biol. 2013;95(2):215-24.
Khanna KM, Lefrançois L. B cells, not just for antibody anymore. Immunity. 2012;36(3):315-7.
Khanna KM, Lefrançois L. Imaging-and Imagining-Immune Responses to Infections: Laser-scanning confocal microscopy pinpoints responses of immune system components to bacterial infections in situ. Microbe Wash DC. 2011;6(2):63-68.
Thangada S*, Khanna KM*, Blaho VA, Oo ML, Im DS, Guo C, Lefrançois L, Hla T. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med. 2010;207(7):1475-83. *Co-First Author.
Khanna KM, Blair DA, Vella AT, McSorley SJ, Datta SK, Lefrançois L. T cell and APC dynamics in situ control the outcome of vaccination. J Immunol. 2010;185(1):239-52.
Khanna KM, Aguila CC, Redman JM, Suarez-Ramirez JE, Lefrançois L, Cauley LS. In situ imaging reveals different responses by naive and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol. 2008;38(12):3304-15.
Knickelbein JE, Khanna KM, Yee MB, Baty CJ, Kinchington PR, Hendricks RL. Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency. Science. 2008;322(5899):268-71.
Obar JJ, Khanna KM, Lefrançois L. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity. 2008;28(6):859-69.
Khanna KM, Lefrançois L. Geography and plumbing control the T cell response to infection. Immunol Cell Biol. 2008;86(5):416-22. Review.
Khanna KM, McNamara JT, Lefrançois L. In situ imaging of the endogenous CD8 T cell response to infection. Science. 2007;318(5847):116-20.
Turner DL, Cauley LS, Khanna KM, Lefrançois L. Persistent antigen presentation after acute vesicular stomatitis virus infection. J Virol. 2007;81(4):2039-46.
Sheridan BS, Khanna KM, Frank GM, Hendricks RL. Latent virus influences the generation and maintenance of CD8+ T cell memory. J Immunol. 2006;177(12):8356-64.
Cose S, Brammer C, Khanna KM, Masopust D, Lefrançois L. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur J Immunol. 2006;36(6):1423-33.
Khanna KM, Lepisto AJ, Decman V, Hendricks RL. Immune control of herpes simples virus during latency. Curr Opin Immunol. 2004;16(4):463-9. Review.
Khanna KM, Lepisto AJ, Hendricks RL. Immunity to latent viral infection: many skirmishes but few fatalities. Trends Immunol. 2004;25(5):230-4. Review.
Khanna KM, Bonneau RH, Kinchington PR, Hendricks RL. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity. 2003;18(5):593-603.
Niehaus GD, Ervin E, Patel A, Khanna K, Vanek VW, Fagan DL. Circadian variation in cell-adhesion molecule expression by normal human leukocytes. Can J Physiol Pharmacol. 2002;(80):935-40.
Liu T, Khanna KM, Carriere BN, Hendricks RL. Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons. J Virol. 2001;75(22):11178-84.
Liu T, Khanna KM, Chen X, Fink DJ, Hendricks RL. CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J Exp Med. 2000;191(9):1459-66.
Bee GCW, Lokken-Toyli KL, Yeung ST, Rodriguez L, Zangari T, Anderson EE, Ghosh S, Rothlin CV, Brodin P, Khanna KM, Weiser JN. Age-depedent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. Immunity. 2023 Apr 5:S1074-7613(23)00138-3. doi: 10.1016/j.immuni.2023.03.018. Online ahead of print.PMID: 37059107
Chen F, El-Naccache DW, Pnessa JJ, Lemenze A, Espinosa V, Wu W, Lothstein K, Jin L, Antao O, Weinstein JS, Damani-Yokota P, Khanna K, Murray PJ, Rivera A, Siracusa MC and Gause WC. Helminth resistance is mediated by differential activation of recruited monocyte-derived alveolar macrophages and arginine depletion. Cell Reports. 2022; 38(2), 1033-1035.
Damani-Yokota P, Yeung ST, Khanna KM. Beyond neutralization for BNT162b2 mRNA vaccination. Cell Host Microbe. 2021 Jul 14;29(7):1033-1035. doi: 10.1016/j.chom.2021.06.013. PMID: 34265240; PMCID: PMC8279510.
Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9. PMID: 34048708; PMCID: PMC8106883.
Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, García-Sastre A, Blander JM. TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nat Immunol. 2021 Apr;22(4):497-509. doi: 10.1038/s41590-021-00903-7. Epub 2021 Mar 31. PMID: 33790474.
Sulaiman I, Chung M, Angel L, Tsay JJ, Wu BG, Yeung ST, Krolikowski K, Li Y, Duerr R, Schluger R, Thannickal SA, Koide A, Rafeq S, Barnett C, Postelnicu R, Wang C, Banakis S, Perez-Perez L, Jour G, Shen G, Meyn P, Carpenito J, Liu X, Ji K, Collazo D, Labarbiera A, Amoroso N, Brosnahan S, Mukherjee V, Kaufman D, Bakker J, Lubinsky A, Pradhan D, Sterman DH, Weiden M, Hegu A, Evans L, Uyeki TM, Clemente JC, De Wit E, Schmidt AM, Shopsin B, Desvignes L, Wang C, Li H, Zhang B, Forst CV, Koide S, Stapleford KA, Khanna KM, Ghedin E, Segal LN. Microbial signatures in the lower airways of mechanically ventilated COVID19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258. doi: 10.1038/s41564-021-00961-5. Epub 2021 Aug 31.PMID: 34465900
Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020 Dec 23;183(7):2036-2039. doi: 10.1016/j.cell.2020.12.008. Erratum for: Cell. 2020 Jan 9;180(1):79-91.e16. PMID: 33357400; PMCID: PMC7891798.
Ryu S, Shchukina I, Youm YH, Qing H, Hilliard BK, Dlugos T, Zhang X, Yasumoto Y, Booth CJ, Fernández-Hernando C, Suárez Y, Khanna KM, Horvath TL, Dietrich MO, Artyomov MN, Wang A, Dixit VD. Ketogenesis restrains aging-induced exacerbation of COVID in a mouse model. bioRxiv [Preprint]. 2020 Sep 12:2020.09.11.294363. doi: 10.1101/2020.09.11.294363. Update in: Elife. 2021 Jun 21;10: PMID: 33236006; PMCID: PMC7685240.
Imperato JN, Xu D, Romagnoli PA, Qiu Z, Perez P, Khairallah C, Pham QM, Andrusaite A, Bravo-Blas A, Milling SWF, Lefrancois L, Khanna KM, Puddington L, Sheridan BS. Mucosal CD8 T Cell Responses Are Shaped by Batf3-DC After Foodborne Listeria monocytogenes Infection. Front Immunol. 2020 Sep 11;11:575967. doi: 10.3389/fimmu.2020.575967. PMID: 33042159; PMCID: PMC7518468.
Das Mohapatra A, Tirrell I, Benechet AP, Pattnayak S, Khanna KM, Srivastava PK. Cross-dressing of CD8α+ dendritic cells with antigens from live mouse tumor cells is a major mechanism of cross-priming. Cancer Immunol Res. 2020 Aug 5:canimm.0248.2020. doi: 10.1158/2326-6066.CIR-20-0248. Online ahead of print.PMID: 32759362
Ural BB, Yeung ST, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, Samji T, Sawai CM, Jang G, Perez OA, Pham Q, Maher L, Loke P, Dittmann M, Reizis B, Khanna KM. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties. Sci Immunol. 2020 Mar 27;5(45):eaax8756. doi: 10.1126/sciimmunol.aax8756.PMID: 32220976
Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12. PMID: 31406379
Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. Systemic TLR2 tolerance enhances central nervous system remyelination. J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID: 31351476
Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21. PMID: 30799265
Masters AR, Jellison ER, Puddington L, Khanna KM, Haynes L. Attrition of T Cell Zone Fibroblastic Reticular Cell Number and Function in Aged Spleens. Immunohorizons. 2018 May;2(5):155-163. doi: 10.4049/immunohorizons.1700062. Epub 2018 Jul 23. PMID: 30706058
Grenier JM, Yeung ST, Khanna KM. Combination Immunotherapy: Taking Cancer Vaccines to the Next Level. Front Immunol. 2018 Mar 22;9:610. doi: 10.3389/fimmu.2018.00610. eCollection 2018. Review. PMID: 29623082
Ghosh M, Thangada S, Dasgupta O, Khanna KM, Yamase HT, Kashgarian M, Hla T, Shapiro LH, Ferrer FA. Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction. PLoS One. 2018 Mar 8;13(3):e0194053. doi: 10.1371/journal.pone.0194053. eCollection 2018. PMID: 29518138
Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM. Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective against Solid Skin Tumors. Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017. PMID: 29387061
Huang K, Mukherjee S, DesMarais V, Albanese JM, Rafti E, Draghi Ii A, Maher LA, Khanna KM, Mani S, Matson AP. Targeting the PXR-TLR4 signaling pathway to reduce intestinal inflammation in an experimental model of necrotizing enterocolitis. Pediatr Res. 2018 May;83(5):1031-1040. doi: 10.1038/pr.2018.14. Epub 2018 Feb 21. PMID: 29360809
Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM. CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Sci Immunol. 2017 Oct 6;2(16). pii: eaah5520. doi: 10.1126/sciimmunol.aah5520. PMID: 28986418
Menon M, Benechet AP, Khanna KM. Visualizing Endogenous Effector T Cell Egress from the Lymph Nodes. Methods Mol Biol. 2017;1591:59-71. doi: 10.1007/978-1-4939-6931-9_5. PMID: 28349475
Samji T, Khanna KM. Understanding memory CD8+ T cells. Immunol Lett. 2017 May;185:32-39. doi: 10.1016/j.imlet.2017.02.012. Epub 2017 Mar 6. Review. PMID: 28274794
Qiu Z, Cervantes JL, Cicek BB, Mukherjee S, Venkatesh M, Maher LA, Salazar JC, Mani S, Khanna KM. Pregnane X Receptor Regulates Pathogen-Induced Inflammation and Host Defense against an Intracellular Bacterial Infection through Toll-like Receptor 4. Sci Rep. 2016.
Romagnoli PA, Fu HH, Qiu Z, Khairallah C, Pham QM, Puddington L, Khanna KM, Lefrancois L, Sheridan BS. Differentiation of distinct long-lived memory CD4 T cells in intestinal tissues after oral Listeria monocytogenes infection. Mucosal Immunol. 2016.
Romagnoli PA, Sheridan BS, Pham QM, Lefrancois L, Khanna KM. IL-17A-producing resident memory γδ T cells orchestrate the innate immune response to secondary oral Listeria monocytogenes infection. Proc Natl Acad Sci USA. 2016;113(30):8502-7.
Svedova J, Tsurutani N, Liu W, Khanna KM, Vella AT. TNF and CD28 signaling play unique but complementary roles in the systemic recruitment of innate immune cells after staphylococcus aureus Enterotoxin A inhalation. J Immunol. 2016;196(11):4510-21.
Benechet AP, Menon M, Xu D, Samji T, Maher L, Murooka TT, Mempel TR, Sheridan BS, Lemoine FM, Khanna KM. T cell-intrinsic S1PR1 regulates endogenous effector T-cell egress dynamics from lymph nodes during infection. Proc Natl Acad Sci USA. 2016;113(8):2182-7.
Qiu Z, Grenier JM, Khanna KM. Reviving virus based cancer vaccines by using cytomegalovirus vectors expressing modified tumor antigens. Oncoimmunology. 2015;5(1):e1056974.
Sharma N, Benechet AP, Lefrançois L, Khanna KM. CD8 T Cells Enter the Splenic T Cell Zones Independently of CCR7, but the Subsequent Expansion and Trafficking Patterns of Effector T Cells after Infection Are Dysregulated in the Absence of CCR7 Migratory Cues. J Immunol. 2015;195(11):5227-36.
Plumlee CR, Obar JJ, Colpitts SL, Jellison ER, Haining WN, Lefrançois L, Khanna KM. Early Effector CD8 T Cells Display Plasticity in Populating the Short-Lived Effector and Memory-Precursor Pools Following Bacterial or Viral Infection. Sci Rep. 2015;5:12264.
Hill TM, Gilchuk P, Cicek BB, Osina MA, Boyd KL, Durrant DM, Metzger DW, Khanna KM, Joyce S. Border Patrol Gone Awry: Lung NKT Cell Activation by Francisella tularensis Exacerbates Tularemia-Like Disease. PLoS Pathogen. 2015;11(6):e1004975.
Fujiwara M, Anstadt EJ, Khanna KM, Clark RB. Cbl-b-deficient mice express alterations in trafficking-related molecules but retain sensitivity to the multiple sclerosis therapeutic agent, FTY720. Clin Immunol. 2015;158(1):103-13.
Qiu Z, Huang H, Grenier JM, Perez OA, Smilowitz HM, Adler B, Khanna KM. Cytomegalovirus-Based Vaccine Expressing a Modified Tumor Antigen Induces Potent Tumor-Specific CD8(+) T-cell Response and Protects Mice from Melanoma. Cancer Immunol Res. 2015;3(5):536-46.
Benechet AP, Menon M, Khanna KM. Visualizing T Cell Migration in situ. Front Immunol. 2014;5:363.
Venkatesh M, Mukherjee S, Wang H, Li H, Sun K, Benechet AP, Qiu Z, Maher L, Redinbo MR, Phillips RS, Fleet JC, Kortagere S, Mukherjee P, Fasano A, Le Ven J, Nicholson JK, Dumas ME, Khanna KM*, Mani S*. Symbiotic bacterial metabolites regulate gastrointestinal barrier function via the xenobiotic sensor PXR and Toll-like receptor 4. Immunity. 2014;41(2):296-310. *Co-corresponding Authors.
Wu T, Hu Y, Lee Y-T, Bouchard KR, Benechet A, Khanna K, Cauley LS. Lung-resident memory CD8 T cells (TRM) are indispensible for optimal cross-protection against pulmonary virus infection. J Leukoc Biol. 2013;95(2):215-24.
Khanna KM, Lefrançois L. B cells, not just for antibody anymore. Immunity. 2012;36(3):315-7.
Khanna KM, Lefrançois L. Imaging-and Imagining-Immune Responses to Infections: Laser-scanning confocal microscopy pinpoints responses of immune system components to bacterial infections in situ. Microbe Wash DC. 2011;6(2):63-68.
Thangada S*, Khanna KM*, Blaho VA, Oo ML, Im DS, Guo C, Lefrançois L, Hla T. Cell-surface residence of sphingosine 1-phosphate receptor 1 on lymphocytes determines lymphocyte egress kinetics. J Exp Med. 2010;207(7):1475-83. *Co-First Author.
Khanna KM, Blair DA, Vella AT, McSorley SJ, Datta SK, Lefrançois L. T cell and APC dynamics in situ control the outcome of vaccination. J Immunol. 2010;185(1):239-52.
Khanna KM, Aguila CC, Redman JM, Suarez-Ramirez JE, Lefrançois L, Cauley LS. In situ imaging reveals different responses by naive and memory CD8 T cells to late antigen presentation by lymph node DC after influenza virus infection. Eur J Immunol. 2008;38(12):3304-15.
Knickelbein JE, Khanna KM, Yee MB, Baty CJ, Kinchington PR, Hendricks RL. Noncytotoxic lytic granule-mediated CD8+ T cell inhibition of HSV-1 reactivation from neuronal latency. Science. 2008;322(5899):268-71.
Obar JJ, Khanna KM, Lefrançois L. Endogenous naive CD8+ T cell precursor frequency regulates primary and memory responses to infection. Immunity. 2008;28(6):859-69.
Khanna KM, Lefrançois L. Geography and plumbing control the T cell response to infection. Immunol Cell Biol. 2008;86(5):416-22. Review.
Khanna KM, McNamara JT, Lefrançois L. In situ imaging of the endogenous CD8 T cell response to infection. Science. 2007;318(5847):116-20.
Turner DL, Cauley LS, Khanna KM, Lefrançois L. Persistent antigen presentation after acute vesicular stomatitis virus infection. J Virol. 2007;81(4):2039-46.
Sheridan BS, Khanna KM, Frank GM, Hendricks RL. Latent virus influences the generation and maintenance of CD8+ T cell memory. J Immunol. 2006;177(12):8356-64.
Cose S, Brammer C, Khanna KM, Masopust D, Lefrançois L. Evidence that a significant number of naive T cells enter non-lymphoid organs as part of a normal migratory pathway. Eur J Immunol. 2006;36(6):1423-33.
Khanna KM, Lepisto AJ, Decman V, Hendricks RL. Immune control of herpes simples virus during latency. Curr Opin Immunol. 2004;16(4):463-9. Review.
Khanna KM, Lepisto AJ, Hendricks RL. Immunity to latent viral infection: many skirmishes but few fatalities. Trends Immunol. 2004;25(5):230-4. Review.
Khanna KM, Bonneau RH, Kinchington PR, Hendricks RL. Herpes simplex virus-specific memory CD8+ T cells are selectively activated and retained in latently infected sensory ganglia. Immunity. 2003;18(5):593-603.
Niehaus GD, Ervin E, Patel A, Khanna K, Vanek VW, Fagan DL. Circadian variation in cell-adhesion molecule expression by normal human leukocytes. Can J Physiol Pharmacol. 2002;(80):935-40.
Liu T, Khanna KM, Carriere BN, Hendricks RL. Gamma interferon can prevent herpes simplex virus type 1 reactivation from latency in sensory neurons. J Virol. 2001;75(22):11178-84.
Liu T, Khanna KM, Chen X, Fink DJ, Hendricks RL. CD8(+) T cells can block herpes simplex virus type 1 (HSV-1) reactivation from latency in sensory neurons. J Exp Med. 2000;191(9):1459-66.