Stephen T. Yeung, MS/M.Phil/PhDStephen graduated from the University of California Irvine in 2013 with a BA in Public Health Policy: Healthcare Management and Policy and New York University in 2018 with a MS in Pathology and in 2020 with a M.Phil in Pathology and Ph.D. in Basic Medical Sciences: Immunology and Inflammation. During his undergrad, Stephen worked in Dr. Frank M. LaFerla Lab studying the role of brain injury on adult neurogenesis. Stephen also worked in the Public Health field investigating preventive measures for headaches and alcohol use and dependence among undergraduate students. Prior to beginning his PhD, Stephen continued to work in Dr. Frank M. LaFerla Lab and Dr. Mathew Blurton-Jones Lab studying the therapeutic potential of human neural stem cells as a treatment for Alzheimer’s disease, the effects of repeated cognitive training on Alzheimer’s pathology, and the role of the adaptive immune system on Alzheimer’s disease pathogenesis. At UCHC, his studies focus on understanding the role of a subset of intestinal macrophages during Shiga toxin Citrobacter rodentium infection and the ontogeny, maintenance, and function of non-lymphoid tissue resident macrophages.
Upon transitioning to NYU, his studies shifted towards understanding the role of tissue resident macrophage subsets in regulating host defense against microbes. Stephen's Ph.D. work investigated the role of tissue resident macrophages in regulating systemic inflammatory diseases (septic shock and Staph aureus/Listeria infections). Upon graduation, Stephen was recruited to Weill Cornell Medicine as a Senior Research Scientist in the laboratory of Dr. Lishomwa Ndhlovu to study the role of myeloid cells in HIV pathogenesis in models of human, mouse, and non-human primates. After 2 years, Stephen came back to NYU as a Senior Research Scientist in the lab, with his research focus on host defense against infections (SARS-CoV-2, mTB, Staph aureus, Listeria, Influenza). Currently, Stephen is setting up his own independent research program and is training undergraduate and high school students. Research Interest: Neurobiology, Behavioral Neuroscience, Neurobiology of Disease, Patient Outcome, Public Health, Public Policy, Innate Immunology, Innate Immune Receptors, Host-Pathogen Interaction, Microscopy, Biomedical Engineering, Transgenic systems Awards/Accolades:
Fun Fact: When Stephen is not in lab, he spends his time advocating for the LGBTQ community, aiding in community development, and spending time wandering aimlessly in Manhattan. Hometown: Baldwin Park, CA B.A. Public Health Policy: Healthcare Management and Policy, Minor: Biomedical Engineering, University of California, Irvine - 2013 M.S. Pathology, New York University - 2018 M.Phil Pathology, New York University - 2020 Ph.D. Pathology, New York University - 2020 |
Publications |
2023
Premeaux TA*, Yeung ST*, Pillai SK, Ndhlovu LC. Elevated Galectin-9 across the human brain correlates with HIV neuropathology and detrimental cognitive states. J Neurovirol. 2023 May 26. doi: 10.1007/s13365-023-01149-9. Online ahead of print.PMID: 37233903 *Co-first Author Rodriguez-Rodriguez BA, Ciabattoni GO, Duerr R, Valero-Jimenez AM, Yeung ST, Crosse KM, Schinlever AR, Bernard-Raichon L, Rodriguez Galvan J, McGrath ME, Vashee S, Xue Y, Loomis CA, Khanna KM, Cadwell K, Desvignes L, Frieman MB, Ortigoza MB, Dittmann M. A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8. Nat Commun. 2023 May 25;14(1):3026. doi: 10.1038/s41467-023-38783-0.PMID: 37230979. Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani ZY, Niki T, Ndhlovu LC, Greenland JR, Pillai SK. Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells. J Mol Cell Biol. 2023 May 1:mjad030. doi: 10.1093/jmcb/mjad030. Online ahead of print.PMID: 37127426 Yeung ST, Ovando LJ, Russo AJ, Rathinam VAK, Khanna KM. CD169+ macrophage intrinsic IL-10 production regulates immune homeostasis during sepsis. Cell Reports. Cell Rep. 2023 Mar 28;42(3):112171. doi: 10.1016/j.celrep.2023.112171. Epub 2023 Mar 2.PMID: 36867536 Bee GCW, Lokken-Toyli KL, Yeung ST, Rodriguez L, Zangari T, Anderson EE, Ghosh S, Rothlin CV, Brodin P, Khanna KM, Weiser JN. Age-dependent differences in efferocytosis determine the outcome of opsonophagocytic protection from invasive pathogens. Immunity. 2023 Apr 5:S1074-7613(23)00138-3. doi: 10.1016/j.immuni.2023.03.018. Online ahead of print.PMID: 37059107 2022 Rodriguez-Rodriguez BA, Ciabattoni GO, Valero-Jimenez AM, Crosse KM, Schinlever AR, Galvan JJR, Duerr R, Yeung ST, McGrath ME, Loomis C, Khanna KM, Desvignes L, Frieman MF, Ortigoza MB, Dittmann M. A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8. bioRxiv. 2022 Oct 24:2022.10.04.510658. doi: 10.1101/2022.10.04.510658. Preprint.PMID: 36238716 Du L, Bouzidi MS, Gala A, Deiter F, Billaud JN, Yeung ST, Dabral P, Jin J, Simmons G, Dossani Z, Niki T, Ndhlovu LC, Greenland JR, Pillai SK. Human Galectin-9 Potently Enhances SARS-CoV-2 Replication and Inflammation in Airway Epithelial Cells. bioRxiv. 2022 May 16:2022.03.18.484956. doi: 10.1101/2022.03.18.484956. Preprint.PMID: 35378763 Yeung ST, Premeaux TA, Du L, Niki T, Pillai SK, Khanna KM, Ndhlovu LC. Galectin-9 protects humanized-ACE2 immunocompetent mice from SARS-CoV-2 infection. Front Immunol. 2022 Oct 17;13:1011185. doi: 10.3389/fimmu.2022.1011185. eCollection 2022.PMID: 36325323 Rathnasinghe R, Jangra S, Ye C, Cupic A, Singh G, Martínez-Romero C, Mulder LCF, Kehrer T, Yildiz S, Choi A, Yeung ST, Mena I, Gillespie V, De Vrieze J, Aslam S, Stadlbauer D, Meekins DA, McDowell CD, Balaraman V, Corley MJ, Richt JA, De Geest BG, Miorin L; PVI study group; Krammer F, Martinez-Sobrido L, Simon V, García-Sastre A, Schotsaert M. Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera. Nat Commun. 2022 Jul 7;13(1):3921. doi: 10.1038/s41467-022-30763-0.PMID: 35798721 Premeaux TA, Moser CB, McKhann A, Hoenigl M, Yeung ST, Pang APS, Corley MJ, Lederman MM, Landay AL, Gianella S, Ndhlovu LC. Monitoring Circulating Immune Checkpoint Proteins as Predictors of Non-AIDS Morbid Events in People With HIV Initiating Antiretroviral Therapy. Open Forum Infect Dis. 2022 Jan 21;9(3):ofab570. doi: 10.1093/ofid/ofab570. eCollection 2022 Mar.PMID: 35146038 Davis NB and Yeung ST. Transgender Equity in the Workplace: A Systematic Review. Journal of Workplace Rights. Premeaux TA, Yeung ST, Bukhari Z, Bowler S, Alpan O, Gupta R, Ndhlovu LC. Emerging Insights on Caspases in COVID-19 Pathogenesis, Sequelae, and Directed Therapies. Front Immunol. 2022 Feb 21;13:842740. doi: 10.3389/fimmu.2022.842740. eCollection 2022.PMID: 35265086 Plassmeyer M, Alpan O, Corley MJ, Premeaux TA, Lillard K, Coatney P, Vaziri T, Michalsky S, Pang APS, Bukhari Z, Yeung ST, Evering TH, Naughton G, Latterich M, Mudd P, Spada A, Rindone N, Loizou D, Ulrik Sønder S, Ndhlovu LC, Gupta R. Caspases and therapeutic potential of caspase inhibitors in moderate-severe SARS-CoV-2 infection and long COVID. Allergy. 2022 Jan;77(1):118-129. doi: 10.1111/all.14907. Epub 2021 Jun 2.PMID: 33993490 2021 Sulaiman I, Chung M, Angel L, Tsay JJ, Wu BG, Yeung ST, Krolikowski K, Li Y, Duerr R, Schluger R, Thannickal SA, Koide A, Rafeq S, Barnett C, Postelnicu R, Wang C, Banakis S, Pérez-Pérez L, Shen G, Jour G, Meyn P, Carpenito J, Liu X, Ji K, Collazo D, Labarbiera A, Amoroso N, Brosnahan S, Mukherjee V, Kaufman D, Bakker J, Lubinsky A, Pradhan D, Sterman DH, Weiden M, Heguy A, Evans L, Uyeki TM, Clemente JC, de Wit E, Schmidt AM, Shopsin B, Desvignes L, Wang C, Li H, Zhang B, Forst CV, Koide S, Stapleford KA, Khanna KM, Ghedin E, Segal LN. Microbial signatures in the lower airways of mechanically ventilated COVID-19 patients associated with poor clinical outcome. Nat Microbiol. 2021 Oct;6(10):1245-1258. doi: 10.1038/s41564-021-00961-5. Epub 2021 Aug 31.PMID: 34465900 Damani-Yokota P, Yeung ST, Khanna KM. Beyond neutralization for BNT162b2 mRNA vaccination. Cell Host Microbe. 2021 Jul 14;29(7):1033-1035. doi: 10.1016/j.chom.2021.06.013.PMID: 34265240 Corley MJ, Pang APS, Dody K, Mudd PA, Patterson BK, Seethamraju H, Bram Y, Peluso MJ, Torres L, Iyer NS, Premeaux TA, Yeung ST, Chandar V, Borczuk A, Schwartz RE, Henrich TJ, Deeks SG, Sacha JB, Ndhlovu LC. Genome-wide DNA methylation profiling of peripheral blood reveals an epigenetic signature associated with severe COVID-19. J Leukoc Biol. 2021 Jul;110(1):21-26. doi: 10.1002/JLB.5HI0720-466R. Epub 2021 Jan 19.PMID: 33464637 Lu Q, Liu J, Zhao S, Gomez Castro MF, Laurent-Rolle M, Dong J, Ran X, Damani-Yokota P, Tang H, Karakousi T, Son J, Kaczmarek ME, Zhang Z, Yeung ST, McCune BT, Chen RE, Tang F, Ren X, Chen X, Hsu JCC, Teplova M, Huang B, Deng H, Long Z, Mudianto T, Jin S, Lin P, Du J, Zang R, Su TT, Herrera A, Zhou M, Yan R, Cui J, Zhu J, Zhou Q, Wang T, Ma J, Koralov SB, Zhang Z, Aifantis I, Segal LN, Diamond MS, Khanna KM, Stapleford KA, Cresswell P, Liu Y, Ding S, Xie Q, Wang J. SARS-CoV-2 exacerbates proinflammatory responses in myeloid cells through C-type lectin receptors and Tweety family member 2. Immunity. 2021 Jun 8;54(6):1304-1319.e9. doi: 10.1016/j.immuni.2021.05.006. Epub 2021 May 9.PMID: 34048708 Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, García-Sastre A, Blander JM. TAP dysfunction in dendritic cells enables noncanonical cross-presentation for T cell priming. Nat Immunol. 2021 Apr;22(4):497-509. doi: 10.1038/s41590-021-00903-7. Epub 2021 Mar 31.PMID: 33790474 2020 Ural BB*, Yeung ST*, Damani-Yokota P, Devlin JC, de Vries M, Vera-Licona P, Samji T, Sawai CM, Jang G, Perez OA, Pham Q, Maher L, Loke P, Dittmann M, Reizis B, Khanna KM. Identification of a nerve-associated, lung-resident interstitial macrophage subset with distinct localization and immunoregulatory properties. Sci Immunol. 2020 Mar 27;5(45):eaax8756. doi: 10.1126/sciimmunol.aax8756.PMID: 32220976 *Co-first Author Lee JY, Hall JA, Kroehling L, Wu L, Najar T, Nguyen HH, Lin WY, Yeung ST, Silva HM, Li D, Hine A, Loke P, Hudesman D, Martin JC, Kenigsberg E, Merad M, Khanna KM, Littman DR. Serum Amyloid A Proteins Induce Pathogenic Th17 Cells and Promote Inflammatory Disease. Cell. 2020 Jan 9;180(1):79-91.e16. doi: 10.1016/j.cell.2019.11.026. Epub 2019 Dec 19. PMID: 31866067 2019 Guillamot M, Ouazia D, Dolgalev I, Yeung ST, Kourtis N, Dai Y, Corrigan K, Zea-Redondo L, Saraf A, Florens L, Washburn MP, Tikhonova AN, Malumbres M, Gong Y, Tsirigos A, Park C, Barbieri C, Khanna KM, Busino L, Aifantis I. The E3 ubiquitin ligase SPOP controls resolution of systemic inflammation by triggering MYD88 degradation. Nat Immunol. 2019 Sep;20(9):1196-1207. doi: 10.1038/s41590-019-0454-6. Epub 2019 Aug 12. PMID: 31406379 Wasko NJ, Kulak MH, Paul D, Nicaise AM, Yeung ST, Nichols FC, Khanna KM, Crocker S, Pachter JS, Clark RB. Systemic TLR2 tolerance enhances central nervous system remyelination. J Neuroinflammation. 2019 Jul 27;16(1):158. doi: 10.1186/s12974-019-1540-2. PMID: 31351476 Lin JD, Nishi H, Poles J, Niu X, Mccauley C, Rahman K, Brown EJ, Yeung ST, Vozhilla N, Weinstock A, Ramsey SA, Fisher EA, Loke P. Single-cell analysis of fate-mapped macrophages reveals heterogeneity, including stem-like properties, during atherosclerosis progression and regression. JCI Insight. 2019 Feb 21;4(4). pii: 124574. doi: 10.1172/jci.insight.124574. eCollection 2019 Feb 21. PMID: 30830865 Lubkin A, Lee WL, Alonzo F 3rd, Wang C, Aligo J, Keller M, Girgis NM, Reyes-Robles T, Chan R, O'Malley A, Buckley P, Vozhilla N, Vasquez MT, Su J, Sugiyama M, Yeung ST, Coffre M, Bajwa S, Chen E, Martin P, Kim SY, Loomis C, Worthen GS, Shopsin B, Khanna KM, Weinstock D, Lynch AS, Koralov SB, Loke P, Cadwell K, Torres VJ. Staphylococcus aureus Leukocidins Target Endothelial DARC to Cause Lethality in Mice. Cell Host Microbe. 2019 Mar 13;25(3):463-470.e9. doi: 10.1016/j.chom.2019.01.015. Epub 2019 Feb 21. PMID: 30799265 2018 Grenier JM, Yeung ST, Khanna KM. Combination Immunotherapy: Taking Cancer Vaccines to the Next Level. Front Immunol. 2018 Mar 22;9:610. doi: 10.3389/fimmu.2018.00610. eCollection 2018. Review. PMID: 29623082 Grenier JM, Yeung ST, Qiu Z, Jellison ER, Khanna KM. Combining Adoptive Cell Therapy with Cytomegalovirus-Based Vaccine Is Protective against Solid Skin Tumors. Front Immunol. 2018 Jan 16;8:1993. doi: 10.3389/fimmu.2017.01993. eCollection 2017. PMID: 29387061 2017 Perez OA, Yeung ST, Vera-Licona P, Romagnoli PA, Samji T, Ural BB, Maher L, Tanaka M, Khanna KM. CD169+ macrophages orchestrate innate immune responses by regulating bacterial localization in the spleen. Sci Immunol. 2017 Oct 6;2(16). pii: eaah5520. doi: 10.1126/sciimmunol.aah5520. PMID: 28986418 Marsh SE, Yeung ST, Torres M, Davis JL, Capela A, Poon WW, Blurton-Jones M. Human neural stem cells fail to terminally differentiate, cause tumor-like growths, and provide no cognitive benefits in an immune-deficient transgenic model of Alzheimer’s Disease. Stem Cell Reports. 2017 Feb 14;8(2):235-248. doi: 10.1016/j.stemcr.2016.12.019. PMID: 28199828 2016 Yeung ST*, Lo TCT*, Lee S, Skavinski K, Liao S. Reduction of central neuropathic pain in an Ehlers-Danlos Syndrome patient via Ketamine IV infusion: a case report. J Pain Res. 2016 Sep 15;9:683-687. eCollection 2016. PMID: 27695362*Co-first author Chen W, Abud EM, Yeung ST, Lakatos A, Nassi T, Wang J, Blum D, Buee L, Poon WW, Blurton-Jones M. Increased tauopathy drives microglia-mediated clearance of beta-amyloid. Acta Neuropathol Commun. 2016 Jun 23;4(1):63. doi: 10.1186/s40478-016-0336-1. PMID: 27339073 Marsh SE, Abud EM*, Lakatos A*, Karimzadeh A, Yeung ST, Davtyan H, Fote GM, Lau L, Weinger JG, Lane TE, Inlay MA, Poon WW, Blurton-Jones M. The adaptive immune system restrains Alzheimer’s disease pathogenesis by modulating microglial function. Proc Natl Acad Sci U S A. 2016 Mar 1;113(9):E1316-25. doi: 10.1073/pnas.1525466113. Epub 2016 Feb 16. PMID: 26884167. *Contribute equally 2015 Yeung ST*, Lo TCT*, Lee S, Chang EY. Hematuria following Botox treatment for upper extremity spasticity: a case report. J Pain Res. 2015 Sep 14;8:619-22. doi: 10.2147/JPR.S88658. eCollection 2015. PMID: 26396542 *Co-first author Yeung ST*, Martinez-Coria H*, Ager RR, Rodriguez-Ortiz CJ, Baglietto-Vargas D, LaFerla FM. Repeated cognitive stimulation alleviates memory impairments in an Alzheimer's disease mouse model. Brain Res Bull. 2015 Aug;117:10-5. doi: 10.1016/j.brainresbull.2015.07.001. Epub 2015 Jul 7. Erratum in: Brain Res Bull. 2015 Oct;119(Pt A):104. PMID: 26162480 *Co-first author 2014 Yeung ST*, Myczek K*, Castello N, Baglietto-Vargas D, LaFerla FM. Hippocampal adaptive response following extensive neuronal loss in an inducible transgenic mouse model. PLoS One. 2014 Sep 3;9(9):e106009. doi: 10.1371/journal.pone.0106009. eCollection 2014. PMID: 25184527 *Co-first author Yeung ST*, Myczek K*, Kang AP, Chabrier MA, Baglietto-Vargas D, LaFerla FM (2013). Impact of hippocampal neuronal ablation on neurogenesis and cognition in the aged brain. Neuroscience. 2014 Feb 14;259:214-22. doi: 10.1016/j.neuroscience.2013.11.054. Epub 2013 Dec 4. PMID: 24316470 *Co-first author |